Fromherz Research Projects
Current Projects
Optogenetics
This project is aimed at developing molecular genetic tools and complementary approaches to better understand the development and function of the sensorimotor system in animals. Through the use embryonic chickens as the model, and optogenetics as an excellent non-invasive way to control neuronal activity at will, as well as a special plasmid, we can elucidate this relationship. Current research is focused on understanding the role of proprioceptive neuron activity during embryonic development in proprioception, the means by which animals including humans sense body movement and positioning.
This graphic helps illustrate the nature of optogenetic interactions.
Past Projects
NT-3 Chick Project
The goal of this project was to better understand the mechanism of proprioceptive neurodegeneration linked to Vitamin B6 overdoses in humans using a model organism (namely, chick embryos). This project applied cell biology, biochemistry, and bioinformatics approaches including the use of Western blotting and ELISAs. The chicken proprioceptive system uses the same type of signal peptide and receptor protein as humans, so the hope was that by obtaining information about the temporal pattern of the development in chick embryos, knowledge can be gleaned about the toxicity of Vitamin B6 in human embryos. It was determined the pathway tested was not likely to be a route for toxicity. This knowledge is one step towards opening the door for developing a treatment for those affected by proprioceptive disorders resulting from their mother having consumed too much Vitamin B6.
Pictured are Cole Pero, Amanda Weiss, and Julie Learst presenting their findings at a SVSU student showcase event.